Application of f-f luminescence of terbium ion for determination of non-steroidal anti-inflammatory drug-niflumic acid

Authors
Egorova, A Beltyukova, S Teslyuk, O Karpinchik, V
Citation
A. Egorova et al., Application of f-f luminescence of terbium ion for determination of non-steroidal anti-inflammatory drug-niflumic acid, J PHARM B, 24(5-6), 2001, pp. 1081-1085
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
24
Issue
5-6
Year of publication
2001
Pages
1081 - 1085
Database
ISI
SICI code
0731-7085(200103)24:5-6<1081:AOFLOT>2.0.ZU;2-V
Abstract
A simple, rapid and sensitive luminescence method for determination of nifl umic acid (NFA) is described. The method is based on the intramolecular ene rgy transfer from niflumic acid to terbium ion (Tb3+) in the presence of tr ioctylphosphine oxide (TOPO). Optimum conditions for the formation of the N FA-Tb3+-TOPO ternary complex have been investigated. The calibration graph is linear over the range 0.002-0.02 mug ml(-1). The relative standard devia tion is close to 4%. The recoveries obtained by applying the method to the analysis of urine ranged from 94-102%. (C) 2001 Elsevier Science B.V. All r ights reserved.