MINOCYCLINE AND ETHYLENEDIAMINETETRAACETATE FOR THE PREVENTION OF RECURRENT VASCULAR CATHETER INFECTIONS

Authors
RAAD I BUZAID A RHYNE J HACHEM R DAROUICHE R SAFAR H ALBITAR M SHERERTZ RJ
Citation
I. Raad et al., MINOCYCLINE AND ETHYLENEDIAMINETETRAACETATE FOR THE PREVENTION OF RECURRENT VASCULAR CATHETER INFECTIONS, Clinical infectious diseases, 25(1), 1997, pp. 149-151
Citations number
12
Categorie Soggetti
Microbiology,Immunology,"Infectious Diseases
Journal title
Clinical infectious diseases → ACNP
ISSN journal
10584838
Volume
25
Issue
1
Year of publication
1997
Pages
149 - 151
Database
ISI
SICI code
1058-4838(1997)25:1<149:MAEFTP>2.0.ZU;2-O
Abstract
Three patients with recurrent vascular catheter-related bacteremia wer e successfully treated by allowing a solution of minocycline and ethyl enediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA an d hushing the lumen daily with the same solution, In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum anti microbial activity, may have optimal anticoagulant activity, and may b e highly efficacious in preventing catheter colonization.