Sleep deprivation blunts the nighttime increase in aldosterone release in humans

The aim of this study was to determine the effect of sleep deprivation on t he 24-h profile of aldosterone and its consequences on renal function. Aldo sterone and its main hormonal regulatory factors, ACTH (evaluated by cortis ol measurement) and the renin-angiotensin system [RAS, evaluated by plasma renin activity (PRA) measurement] were determined every 10 min for 24 h in eight healthy subjects in the supine position, once with nocturnal sleep an d once during total 24-h sleep deprivation. Plasma Na+ and K+ were measured every 10 min in four of these subjects. In an additional group of 13 subje cts under enteral nutrition, diuresis, natriuresis and kaliuresis were meas ured once during the sleep period (23.00-07.00 h) and once during a 23.00-0 7.00 hours sleep deprivation period. During sleep deprivation, aldosterone displayed lower plasma levels and pulse amplitude in the 23.00-07.00-hour p eriod than during sleep. Similarly, PRA showed reduced levels and lower pul se frequency and amplitude. Plasma cortisol levels were slightly enhanced d uring sleep deprivation. Overnight profiles of plasma K+ and Na+ were not a ffected. Diuresis and kaliuresis were not influenced by sleep deprivation. In contrast, natriuresis significantly increased during sleep deprivation. This study demonstrates that sleep deprivation modifies the 24-h aldosteron e profile by preventing the nocturnal increase in aldosterone release and l eads to altered overnight hydromineral balance.