Fibrous dysplasia of bone: Management and outcome of 20 cases

Background and Objectives: Fibrous dysplasia of bone is difficult to manage because of its variable clinical course with many different methods of tre atment reported. Therefore we report on our experience. Methods: We reviewed a series of 20 patients with 32 lesions included. The average age at the time of diagnosis was 32 years for monostotic disease, 2 6 years for polyostotic disease, and 3 years for McCune-Albright syndrome. The median follow-up period was 6 years. Functional and radiographic outcom es were scored. Results and Conclusions: Monostotic disease mostly presented with a circums cribed lesion and monitoring was often sufficient. Symptomatic circumscribe d lesions showed satisfactory outcome when treated with curettage, cryosurg ery and bone grafting. Lesions of the extended type were most of all seen i n polyostotic disease and eventually needed operative treatment. In case of bony deformity, corrective osteotomies and rigid internal fixation were pe rformed in addition to curettage, cryosurgery, and bone grafting. In polyos totic disease, expected outcomes were good, but ill McCune-Albright syndrom e, results were uniformly poor. (C) 2001 Wiley-Liss, Inc.