A case of Kaposi sarcoma with HIV-negative and sequence of HHV-8 positive a
nd exclusive rectosigmoid and descending colon involvement without immunode
ficiency is reported. Histologically, in addition to typical features of Ka
posi sarcoma, Cowdry type A inclusions were seen. PCR analysis of the tumor
showed positivity for human herpesvirus 8. Two of the six reported cases o
f Kaposi sarcoma limited to the bowel were from African men before the AIDS
epidemic. (C) 2001 Wiley-Liss, Inc.