Mp. Yang et al., Enhanced phagocytic activity of neutrophils caused by administration of egg white derivatives (EWD) in cats injected with cyclophosphamide (CPA), J VET MED S, 63(3), 2001, pp. 269-274
TO examine ill vivo effects of egg white derivatives (EWD), the numbers of
peripheral blood cells and neutrophil phagocytosis were evaluated in cats i
njected intramuscularly with cyclophosphamide (CPA). There were no changes
in the number of red blood cells (RBC) or packed cell volume (PCV) values r
egardless of oral administration of EWD or injection of CPA. but the number
s of platelets, white blood cells (WBC) and neutrophils in cats administere
d EWD significantly increased (p<0.05 to 0.01) when compared with those in
control cats which received saline solution. In addition, the administratio
n of EWD resulted in a significant enhancement in the phagocytic activity o
f neutrophils (p<0.01) when compared to control cats, suggesting that EWD h
as a stimulating effect on leukocyte progenitors. The numbers of platelets,
WBC and neutrophils, and the phagocytic activity of neutrophils in cats in
jected with CPA alone were significantly lower (p<0.05 to 0.01) than those
in control cats. However, co-administration of EWD to cars injected with CP
A resulted in a significant increase in the numbers of platelets, WBC and n
eutrophils (p<0.05 to 0.01), and in the phagocytic response of neutrophils
(p<0.01) when compared to cats injected with CPA alone. Therefore, these re
sults suggest that co-administration of EWD may be effective in reducing st
,me possible side effects in animals treated with immunosuppressive or anti
tumor agents.