Malignant fibrous histiocytoma (MFH) cells and macrophages/histiocytes have a common antigen recognized by a monoclonal antibody risen against a rat MFH-derived cloned cell line
D. Kumagai et al., Malignant fibrous histiocytoma (MFH) cells and macrophages/histiocytes have a common antigen recognized by a monoclonal antibody risen against a rat MFH-derived cloned cell line, J VET MED S, 63(3), 2001, pp. 333-335
A monoclonal antibody (B9) was generated by using a rat malignant fibrous h
istiocytoma (MFH)-derived cloned cell line (MT-8) as the immunogen. Immunoh
istochemically, B9 reacted specifically with a cytoplasmic antigen of MT-8
cells. Furthermore, B9 immunolabeled another MFH-derived cloned cells (MT-9
) and histiocytic sarcoma cells, as well as macrophages/histiocytes in norm
al and diseased tissues of rats. These findings suggest the presence of a c
ommon antigen recognized by B9 between MFH cells and macrophages/histiocyte
s. This suggests that MFH cells may express histiocytic nature.