Malignant fibrous histiocytoma (MFH) cells and macrophages/histiocytes have a common antigen recognized by a monoclonal antibody risen against a rat MFH-derived cloned cell line

Authors
Kumagai, D Yamate, J Tajima, T Kuwamura, M Kotani, T Sakuma, S
Citation
D. Kumagai et al., Malignant fibrous histiocytoma (MFH) cells and macrophages/histiocytes have a common antigen recognized by a monoclonal antibody risen against a rat MFH-derived cloned cell line, J VET MED S, 63(3), 2001, pp. 333-335
Citations number
14
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY MEDICAL SCIENCE
ISSN journal
09167250 → ACNP
Volume
63
Issue
3
Year of publication
2001
Pages
333 - 335
Database
ISI
SICI code
0916-7250(200103)63:3<333:MFH(CA>2.0.ZU;2-R
Abstract
A monoclonal antibody (B9) was generated by using a rat malignant fibrous h istiocytoma (MFH)-derived cloned cell line (MT-8) as the immunogen. Immunoh istochemically, B9 reacted specifically with a cytoplasmic antigen of MT-8 cells. Furthermore, B9 immunolabeled another MFH-derived cloned cells (MT-9 ) and histiocytic sarcoma cells, as well as macrophages/histiocytes in norm al and diseased tissues of rats. These findings suggest the presence of a c ommon antigen recognized by B9 between MFH cells and macrophages/histiocyte s. This suggests that MFH cells may express histiocytic nature.