Background Choice of treatment for atherosclerosis depends on various clini
cal factors and radiological techniques. We aimed to assess the diagnostic
accuracy of a new three-dimensional magnetic resonance angiography (3D MRA)
strategy for the display of arterial vasculature from supraaortic arteries
to distal runoff vessels in 72 s.
Methods We examined five healthy volunteers and six patients over 6 weeks.
Conventional digital subtraction angiography (DSA) was available as referen
ce standard in all six patients. Magnetic resonance imaging was done on a c
ommercially available 1.5 Tesla scanner. The imaging technique was based on
the acquisition of five 3D data sets in rapid succession with an optimum s
ingle injection protocol.
Findings Compared with conventional catheter angiography, according to the
findings of two independent and masked readers, whole-body MRA had overall
sensitivities of 91% (95% CI 0.76-0.98) and 94% (0.8-0.99), and specificiti
es of 93% (0.85-0.97) and 90% (0.82-0.96) for the detection of substantial
vascular disease (luminal narrowing >50%). Interobserver agreement for asse
ssment of whole-body magnetic angiograms was very good (kappa =0.94: 95% CI
0.9-0.98).
Interpretation The technique provides a comprehensive noninvasive approach
for morphological screening assessment of the arterial vasculature from sup
ra-aortic arteries to the distal runoff arteries.