Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients

Authors
Menges, T Hermans, PWM Little, SG Langefeld, T Boning, O Engel, J Sluijter, M de Groot, R Hempelmann, G
Citation
T. Menges et al., Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients, LANCET, 357(9262), 2001, pp. 1096-1097
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
357
Issue
9262
Year of publication
2001
Pages
1096 - 1097
Database
ISI
SICI code
0140-6736(20010407)357:9262<1096:P4PPAP>2.0.ZU;2-9
Abstract
A single base pair insertion/deletion (4G/5G) promoter polymorphism in the plasminogen-activator-inhibitor-1 (PAI-1) gene is thought to play a part in prognosis after severe trauma. We investigated the relation between outcom e of severe trauma, PAI-1 concentrations. and PAI-1 genotype in 61 patients who had been severely injured. 11 (58%) of 19 patients with genotype 4G/4G did not survive, whereas only eight (28%) of 29 patients with heterozygous genotype 4G/5G, and two (15%) of 13 patients with genotype 5G/5G died. The PAI-1 4G allele is associated with high concentrations of PAI-1 in plasma and a poor survival rate after severe trauma.