Telomerase activity and clinical progression in chronic lymphoproliferative disorders of B-cell lineage

Citation
G. Ballon et al., Telomerase activity and clinical progression in chronic lymphoproliferative disorders of B-cell lineage, LEUK LYMPH, 41(1-2), 2001, pp. 35
Citations number
98
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194 → ACNP
Volume
41
Issue
1-2
Year of publication
2001
Database
ISI
SICI code
1042-8194(200103)41:1-2<35:TAACPI>2.0.ZU;2-D
Abstract
The activation of telomerase, which specifically occurs in neoplastic cells to avoid telomere attrition at each cell division. is a necessary event in tumorigenesis. The evidence that telomerase is also present in normal B ce lls at different levels according to their differentiation and activation s tate makes the study of telomerase activity in B cell tumors particularly i nteresting. This review summarizes data concerning telomerase activity in c hronic lymphoproliferative disorders of B-cell lineage (B-CLD), making sugg estions regarding B-cell development and B-cell tumor histogenesis. The rol e of telomerase activity as a potential prognostic marker, as well as a tar get of new antineoplastic strategies is discussed.