Reversal of fludarabine induced testicular damage in a patient with chronic lymphocytic leukaemia (CLL), by suppression of pituitary-testicular axis using Gonadotrophin releasing hormone (GnRH)

Authors
Chatterjee, R Kottaridis, PD McGarrigle, H Goldstone, AH
Citation
R. Chatterjee et al., Reversal of fludarabine induced testicular damage in a patient with chronic lymphocytic leukaemia (CLL), by suppression of pituitary-testicular axis using Gonadotrophin releasing hormone (GnRH), LEUK LYMPH, 41(1-2), 2001, pp. 213-215
Citations number
10
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194 → ACNP
Volume
41
Issue
1-2
Year of publication
2001
Pages
213 - 215
Database
ISI
SICI code
1042-8194(200103)41:1-2<213:ROFITD>2.0.ZU;2-N
Abstract
We describe a case of a 47 year old man with CLL who was treated with 7 cou rses of fludarabine with simultaneous suppression or his pituitary-testicul ar axis (P-T) with Gonadotrophin releasing hormone (GnRH) and replacement t reatment with testosterone. Despite initial gonadal damage as evident by en docrine and sperm studies. testicular recovery was observed 11 months post treatment. Although spontaneous recovery cannot be ruled out. continous tre atment with GnRH and testosterone may play a crucial role protecting the go nads from the cytotoxic effects of the chemotherapeutic agents.