Central nervous system relapse in a patient with mantle cell lymphoma in continuous clinical and molecular remission at six years since autografting

Although molecular remissions have been frequently observed and associated with low likelihood of relapse in some lymphoid rumours, they are seldom re ported in mantle cell lymphoma (MCL). We performed PCR analysis of a MCL pa tient with central nervous system (CNS) relapse occurring 76 months after a utologous transplantation. Molecular follow-up showed constant absence of P CR-detectable disease, even after the onset of relapse. These data indicate that isolated CNS relapse may occur even after several years of continuous remission and cannot be excluded based on a persistent pattern of molecula r remission. However, the prolonged remission duration observed in this pat ient suggests that achieving PCR-negativity may also be of benefit for MCL patients.