Genetic linkage of childhood atopic dermatitis to psoriasis susceptibilityloci

Authors
Cookson, WOCM Ubhi, B Lawrence, R Abecasis, GR Walley, AJ Cox, HE Coleman, R Leaves, NI Trembath, RC Moffatt, MF Harper, JI
Citation
Wocm. Cookson et al., Genetic linkage of childhood atopic dermatitis to psoriasis susceptibilityloci, NAT GENET, 27(4), 2001, pp. 372-373
Citations number
15
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
27
Issue
4
Year of publication
2001
Pages
372 - 373
Database
ISI
SICI code
1061-4036(200104)27:4<372:GLOCAD>2.0.ZU;2-2
Abstract
We have carried out a genome screen for atopic dermatitis (AD) and have ide ntified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions cor respond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.