Making the most of metal ions

Authors
Horton, NC Perona, JJ
Citation
Nc. Horton et Jj. Perona, Making the most of metal ions, NAT ST BIOL, 8(4), 2001, pp. 290-293
Citations number
36
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
8
Issue
4
Year of publication
2001
Pages
290 - 293
Database
ISI
SICI code
1072-8368(200104)8:4<290:MTMOMI>2.0.ZU;2-X
Abstract
Crystal structures of the homing endonuclease I-Crel bound to substrate DNA and divalent metals show that one metal ion is shared between the two acti ve sites of the enzyme. This arrangement appears uniquely suited to the for mation of double-stranded DNA breaks via a concerted reaction.