Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response

Citation
A. Srikiatkhachorn et al., Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response, NEUROREPORT, 12(5), 2001, pp. 967-971
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
12
Issue
5
Year of publication
2001
Pages
967 - 971
Database
ISI
SICI code
0959-4965(20010417)12:5<967:EOSDON>2.0.ZU;2-3
Abstract
The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nocic eption. Nitroglycerin was infused i.v. to control and serotonin-depleted ra ts. Pial circulation was monitored by intravital fluorescent videomicroscop y and Fos immunoreactivity trigeminal nucleus caudalis neurons was used as an indicator for the cerebrovascular nociception. The results showed that t he degree of nitric oxide-induced pial microvascular dilatation was signifi cantly greater in the serotonin-depleted group than the control. The number of nitric oxide-evoked Fos-immunoreactive cells between the two groups rem ained comparable. The results suggest that though depletion of serotonin ca n facilitate the vascular response to nitric oxide it does not alter the ni tric oxide-induced craniovascular nociceptive response. NeuroReport 12:967- 971 (C) 2001 Lippincott Williams & Wilkins.