Magnesium absorption using stable isotope tracers in healthy children and children treated for leukemia

Intestinal magnesium (Mg) absorption was measured in six healthy children ( control) and in four children treated for acute lymphoblastic leukemia with the single-isotope fecal recovery technique (SIFRT). The objective of this study was to determine Mg absorption in young children with acute lymphobl astic leukemia using stable isotope tracers. Fractional and absolute absorp tion levels determined by SIFRT were not significantly different between ch ildren with acute lymphoblastic leukemia (fractional absorption: 58.3 +/- 1 0.6% [mean +/- SEM], absolute absorption: 3.66 +/- 0.71 mg . kg(-1) . d(-1) , [0.15 +/- 0.03 mmol . kg(-1) . d(-1)]) and control children (fractional a bsorption: 61.4 +/- 7.5%, absolute absorption: 5.69 +/- 0.85 mg . kg(-1) . d(-1), [0.23 +/- 0.03 mmol . kg(-1) . d(-1)]). Average Mg absorption in you ng children (aged 3-8 y) was 60.2 +/- 5.8%. This study describes the first application of the SIFRT to assess Mg absorption in young children and illu strates the feasibility of the SIFRT in this age group to obtain more accur ate information on ME absorption. Nutrition 2001;17:221-224. (C) Elsevier S cience Inc. 2001.