Rescue by birth: Defective placental maturation and late fetal mortality

Objective: To estimate the incidence and lethality of placental maturation defect, and to determine the impact of the pattern of placental dysfunction on the risk of recurrent stillbirth or maternal disease in later life. Methods: Questionnaire and archival analysis of fetal deaths from placental dysfunction at 32-42 weeks (1975-1995 in Zurich), classified as chronic (p arenchyma loss) or acute (maturation defect of the terminal chorionic villi ). Population survey of 17,415 consecutive unselected singleton placentas ( 1994-1998 in Berlin). Results: Of the 71 stillbirths, 34 were due to parenchyma loss and 37 to ma turation defect. Parenchyma loss predominated in the first pregnancy (73.5% compared with 43.2%; P < .05). The risks of recurrent stillbirth and subse quent childlessness did not differ between the two groups. Eleven percent o f mothers whose placenta had maturation defect had diabetes in the index pr egnancy; none of the other women in the group developed diabetes over the 5 -20-year observation period. In the population survey, incidence of maturat ion defect was 5.7%, and was associated with fetal death in 2.3% of cases. Normal placentas were associated with fetal death in 0.033%. Conclusion: Placental maturation defect can be a cause of fetal hypoxia. Al though the risk of stillbirth is 70-fold that of a normal placenta, few aff ected fetuses actually die. The risk of recurrent stillbirth is tenfold abo ve baseline and occurs mostly after 35 weeks' gestation. <(c)> 2001 by The American College of Obstetricians and Gynecologists.