Anticonvulsant properties of N-salicyloyltryptamine in mice

A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential centra l nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ ) and maximal electroshock (MES) models of epilepsy in mice. When administe red concurrently, STP (100 mg/kg ip) significantly reduced the number of an imals that exhibited PTZ-induced seizures and eliminated the extensor refle x of maximal electric-induced seizures test in 50% of the experimental anim als. In addition, it showed protection in the PTZ test by diminishing the d eath rate. (C) 2001 Elsevier Science Inc. All rights reserved.