Synthesis and physiological activities of new acyclic aminophosphonates

The dependence of biological activity of 37 newly synthesized acyclic amino methanephosphonic acid derivatives on their structure was studied. It was f ound that the phytotoxicity of the compounds studied depended on their hydr ophobic parameters, and in a smaller extent on the electronic parameters of the substituents on nitrogen and phosphorus atoms. No phytotoxicity depend ence on the steric parameters of compounds was found. Tested organism was S pirodela oligorrhiza and the parameter studied was the concentration of com pounds causing 50 % growth inhibition (EC50) The test had preliminary chara cter and permitted to eliminate the less promising compounds out of further studies.