Synthesis of some new thieno[2,3-b]pyridines, pyrido[3 ',2 ': 4,5]-thieno[3,2-d]pyrimidines and pyrido[3 ',2 ': 4,5]thieno[3,2-d][1,2,3]-triazines

4-Aryl-3-cyano-2-substituted-methylthiocyclopenta[b]pyridines (3a-c and 4a- i) were prepared by reaction of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-t hiones (2a-c) with chloroacetonitrile or chloro-N-arylacetamides, respectiv ely. On treatment of these products with sodium ethoxide in boiling ethanol , they underwent intramolecular Thorpe-Ziegler cyclization to afford the co rresponding 3-amino-4-aryl-2-functionallized-cyclopenta[e]thieno [2,3-b]pyr idines (5a-c and 6a-i), Most of the latter thienopyridines were used as syn thons for the target cyclopenta[5 ' ,6 ' ]pyrido [3 ' ,2 ' :4,5]thieno[3,2- d]pyrimidines and cyclopenta[5 ' ,6 '] pyrido[3 ' ,2 ' :4,5] thieno[3,2-d][ 1,2, 3]triazines.