A new diterpenoid with antispasmodic activity from Salvia cinnabarina

Authors
Romussi, G Ciarallo, G Bisio, A Fontana, N De Simone, F De Tommasi, N Mascolo, N Pinto, L
Citation
G. Romussi et al., A new diterpenoid with antispasmodic activity from Salvia cinnabarina, PLANTA MED, 67(2), 2001, pp. 153-155
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
2
Year of publication
2001
Pages
153 - 155
Database
ISI
SICI code
0032-0943(200103)67:2<153:ANDWAA>2.0.ZU;2-3
Abstract
From the leaf surface exudate of the aerial parts of Salvia cinnabarina a n ew secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine; acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was compara ble with that obtained for papaverine. The structure of 3,4-secoisopimara-4 (18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.