Lignans as anti-tumor-promoter from the seeds of Hernandia ovigera

Authors
Ito, C Itoigawa, M Ogata, M Mou, XY Tokuda, H Nishino, H Furukawa, H
Citation
C. Ito et al., Lignans as anti-tumor-promoter from the seeds of Hernandia ovigera, PLANTA MED, 67(2), 2001, pp. 166-168
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
2
Year of publication
2001
Pages
166 - 168
Database
ISI
SICI code
0032-0943(200103)67:2<166:LAAFTS>2.0.ZU;2-6
Abstract
Seven lignans (2-8) isolated from the seeds of Hernandia ovigera L. (Hernan diaceae) were tested for their inhibitory effects on Epstein-Barr virus ear ly antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Ra ji cells. Using a primary screening test, all the lignans showed inhibitory activity with IC50 470-590 mol ratio/32 pmol TPA. The data demonstrated th at these lignans might be valuable anti-tumor-promoters.