Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers

Citation
D. Angelopoulou et al., Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers, PLANTA MED, 67(2), 2001, pp. 168-171
Citations number
23
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
2
Year of publication
2001
Pages
168 - 171
Database
ISI
SICI code
0032-0943(200103)67:2<168:EOAHEF>2.0.ZU;2-H
Abstract
Essential oils and hexane extracts from Cistus monspeliensis L. leaves and fruits were analysed by CC-MS. Manoyl oxide and its isomers, 3 beta -hydrox y-manoyl oxide, 3 beta -hydroxy-13-epi-manoyl oxide, as well as 3 beta -ace toxy-13-epi-manoyl oxide were detected for the first time in C. monspeliens is L. Ent-13-epimanoyl oxide was isolated from the hexane extract of leaves and its structure was determined using spectroscopic methods. In vitro cyt otoxic activity of ent-13-epi-manoyl oxide and mixtures of manoyl oxide iso mers at 10(-4) M concentrations ranged from 11.1 to 32.2% of the activity f or a vinblastine control evaluated against nine leukemic cell lines. The re sults showed that the manoyl oxide isomer mixtures as well as ent-13-epi-ma noyl oxide exhibited a slight growth inhibiting activity.