Isoquinoline alkaloids from Thalictrum delavayi

Authors
Li, M Chen, X Tang, QM Zhang, JS
Citation
M. Li et al., Isoquinoline alkaloids from Thalictrum delavayi, PLANTA MED, 67(2), 2001, pp. 189-190
Citations number
12
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
2
Year of publication
2001
Pages
189 - 190
Database
ISI
SICI code
0032-0943(200103)67:2<189:IAFTD>2.0.ZU;2-B
Abstract
Two new protoberberine alkaloids, 2,3,9,10-dimethylenedioxy-8-oxoprotoberbe rine (1) and 2,3,9,10-dimethylenedioxy-1,8-dihydroxyprotoberberine (2), tog ether with nine known isoquinoline-type alkaloids were isolated from the ro ots of Thalictrum delavayi. Their structures were elucidated by spectral me thods. Among these compounds, pseudoprotopine showed competitive inhibition activity by DA receptor binding assay (D-1) in vitro. The competitive inhi bitions were 87.5% (10(-4) M) and 15.6% (10(-6) M), respectively.