The uptake of any screening test is influenced by knowledge of the conditio
n being screened for. In the present study, the knowledge and the source of
knowledge of women offered antenatal screening for Down syndrome (DS) was
assessed by means of a self-administered questionnaire. The questionnaire w
as administered to 300 consecutive women booking for antenatal care, of the
145 (82%) women who completed and returned the questionnaire, 117 (48%) we
re Caucasian, 85 (35%) were Asian born outside the UK, 32 (13%) were Asian
born in the UK and ten (4%) belonged to other categories. Only 30% of the c
ohort had a good understanding of the condition. Racial groups other than C
aucasian had a poorer understanding of DS. The factors which affected knowl
edge of DS included quality of spoken English, knowing an affected child, p
arity and religion. The most significant factor affecting acceptance of scr
eening was the woman's knowledge of DS. The source of information for the c
ondition varied widely: 42% from a general practitioners (GP), 74% from the
hospital and 16% from midwives. The proportion with good knowledge was sim
ilar in those women whose source of information was the GP (45%) and the mi
dwife (41%). These proportions were, however, higher (though not significan
tly) when the source of information was from magazines and newspapers (67%)
and from friends (53%). Uptake of the screening test was best in those wit
h good knowledge (53%) compared to those with poor knowledge (23%) (p < 0.0
2). Between 28% and 66% (depending on the ethnic group) of women had a scre
ening blood test 'allegedly' without knowing why it had been performed. In
order to improve uptake of the screening test for DS there is need for bett
er education and counselling of women attending for antenatal care. Copyrig
ht (C) 2001 John Wiley & Sons, Ltd.