We report the clinical and MRI findings of a 31-year-old healthy immune-com
petent patient who presented following 48 hours of diffuse headache with pr
ogressive and severe rhombencephalomyelitis signs. Cerebral and medullar MR
I confirmed the central nervous system improvement. Serology showed relatio
n with cytomegalovirus infection. Spontaneous improvement was observed and
favoured by ganciclovir administration.