Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration

Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokine tics, which contribute to its unique ability to relieve pain unresponsive t o other potent opiates and its unique dosing and drug interactions. Several guidelines of administration have been established. Physicians who are inv olved in pain management should have a fundamental understanding of methado ne's unique properties.