Renal pelvic carcinoma producing granulocyte colony-stimulating factor: Report of a case

A 69-year-old man was admitted to our hospital because of anorexia and weig ht loss. Abdominal computed tomography showed an irregularly contoured mass in his left renal pelvis. The patient had a remarkable degree of leukocyto sis with no obvious focus of infection. An enzyme immunoassay of the serum revealed a remarkably high concentration of granulocyte colony-stimulating factor (G-CSF). The patient died 6 weeks after admission without a resectio n of the renal pelvic tumor. At autopsy, the tumor involved the pancreas, s tomach, and descending colon. The histopathologic diagnosis was squamous ce ll carcinoma with sarcomatous change. Immunohistochemical staining using an ti-G-CSF antibody demonstrated immunoreactivity in the cancer cells. To our knowledge, this is the first case of renal pelvic carcinoma proven to prod uce G-CSF reported in English.