Dithio-phospholipids for oriented immobilization of proteins to gold surfaces

Authors
Kada, G Riener, CK Gruber, HJ
Citation
G. Kada et al., Dithio-phospholipids for oriented immobilization of proteins to gold surfaces, TETRAHEDR L, 42(14), 2001, pp. 2677-2680
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
14
Year of publication
2001
Pages
2677 - 2680
Database
ISI
SICI code
0040-4039(20010402)42:14<2677:DFOIOP>2.0.ZU;2-0
Abstract
We report the syntheses of phospholipids containing a dithio-group on their hydrophobic end and a choline or a biotin-group on their hydrophilic end. As demonstrated by surface plasmon resonance, a monolayer of these dithioli pids on gold affords specific binding of streptavidin and of biotinylated m olecules in further steps. (C) 2001 Elsevier Science Ltd. Ail rights reserv ed.