Factor VII, tissue factor pathway inhibitor, and monocyte tissue factor indiabetes mellitus: Influence of type of diabetes, obesity index, and age

Changes of the tissue factor (TF) pathway of blood coagulation have been de scribed in diabetes and could be involved in its vascular complications. Ln order to evaluate the influence of the type of diabetes and of the obesity index and age on these changes, factor VII coagulant activity, factor VII antigen, activated factor VII, monocyte TF expression, and plasma Tissue Fa ctor Pathway Inhibitor (TFPI) were examined in 18 Type 1 and 16 Type 2 diab etic patients compared to non-diabetic control subjects matched for age, se x, and obesity index (Types 1 and 2 controls, respectively). Multicomplicat ed patients were excluded. FVIIc, FVIIAg, and FVIIa were higher in Type 2 d iabetic patients and controls than in Type 1 diabetic patients and controls (P<.03). However, FVIIc and FVIIAg were lower in diabetic patients than in their matched controls (P<.03). Monocyte expression of TF was not differen t between Types 1 and 2 diabetic patients and their matched controls except for LPS-stimulated monocyte TF activity which was lower in Type 2 diabetic patients than in Type 2 controls (P<.05). Plasma TFPI was slightly but sig nificantly higher in Type 1 diabetic patients than in Type 1 controls (P=.0 1) and was correlated to glycemia. However, both in Type 2 diabetic patient s and controls, TFPI was higher than in Type 1 controls and was correlated with BMI (P<.0003). These results indicate that in not multicomplicated pat ients, the increase of FVII and TFPI was highly dependent on obesity index and age rather than on diabetes by itself. (C) 2001 Elsevier Science Ltd. A ll rights reserved.