Comparative effects of diet supplementation with l-carnitine and dl-carnitine on ammonia toxicity and hepatic metabolism in rats

AIM: To compare the effects of chronic supplementation with l-carnitine (LC T) and dl-carnitine (DLC) on ammonia toxicity and hepatic metabolism. METHO DS: Three groups of male adult rats were studied: 1) supplemented with LCT (1.2 mmol.kg(-1).d(-1)), 2) supplemented with DLC (1.2 mmol.kg(-1).d(-1)), and 3) control group (COG) not supplemented. RESULTS: The treatment with LC T decreased the toxicity to ammonia. However, the supplementation with DLC did not show any significant effect. In contrast, the effects of the supple mentation with LCT and DLC on hepatic metabolism were quite similar, ie, bo th groups showed: (a) intensified ammonia uptake and decreased urea product ion from ammonia; (b) increased glucose and urea production from L-glutamin e (5 mmol/L). CONCLUSION: The results suggested that LCT supplementation mi ght protect against ammonia toxicity by extra-hepatic mechanisms.