CLINICAL-SIGNIFICANCE OF QUALITATIVE AND QUANTITATIVE CHARACTERISTICSOF BONE-MARROW TRANSPLANT

11 autologous bone marrow transplantations were performed in the Belor us Center for Bone Marrow Transplantation in 1993-1995. The patients h ad acute myeloblastic leukemia in remission (5 cases), acute lymphobla stic leukemia in remission (2 cases), lymphogranulematosis (LGM) stage III (4 cases). The degree and time of recovery of the hematological p arameters are considered in correlation with the number of nucleated c ells (NC), colony-forming units of the culture (CFUc), mixed colony-fo rming units (CFUm), granulocytic-macrophagal colony-forming units (CFU gm), nosological entities and previous chemotherapy. The correlation a nalysis revealed differences between two groups of patients who had un dergone transfusion of the autologous bone marrow: between acute leuke mia patients (group 1) and LGM patients (group 2). In group 1 no corre lations between the studied parameters were recorded. In group 2 there was a distinct correlation between: 2) the number of NC and neutrophi l recovery rate (NRR), r = 0.604; 2) the number of CFUc and leukocyte recovery rate, r = 0.731; 3) the number of CFUc and NRR, r = 0.840; 4) the number of CFUm and the time of neutrophil recovery (r = 0.493). T he hypothesis was suggested that some drugs may damage stem cells of t he bone marrow and possess a cumulative synergic cytotoxic effect on h emopoietic cells precursors.