Influence of the preservative thiomersal on the Interleukin-1-Beta releaseof human peripheral blood cells

Authors
Fischer, M Keller-Stanislawski, B Schober-Bendixen, S Schosser, R Hacke, K Hartung, T Montag, T
Citation
M. Fischer et al., Influence of the preservative thiomersal on the Interleukin-1-Beta releaseof human peripheral blood cells, ALTEX-AL TI, 18(1), 2001, pp. 47-49
Citations number
15
Categorie Soggetti
Health Care Sciences & Services
Journal title
ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN
ISSN journal
09467785 → ACNP
Volume
18
Issue
1
Year of publication
2001
Pages
47 - 49
Database
ISI
SICI code
0946-7785(2001)18:1<47:IOTPTO>2.0.ZU;2-6
Abstract
Several vaccines have been tested in the human whole blood pyrogen testy as an alternative to the rabbit pyrogen test. As reported previously by our g roup, the alternative test system is basically applicable to vaccines. The widely used conservative thiomersal is influencing the test system. Surpris ingly, the induction of fever inducing cytokines by endotoxin contamination s and other pyrogens can be suppressed by thiomersal.