The inhibitory effect of herbal medicine - Dai Kenchu To (DKT) - on the colonic motility in rats in vitro

Authors
Tulimat, MA Ishiguchi, T Kurosawa, S Nakamura, T Takahashi, T
Citation
Ma. Tulimat et al., The inhibitory effect of herbal medicine - Dai Kenchu To (DKT) - on the colonic motility in rats in vitro, AM J CHIN M, 29(1), 2001, pp. 111-118
Citations number
14
Categorie Soggetti
General & Internal Medicine
Journal title
AMERICAN JOURNAL OF CHINESE MEDICINE
ISSN journal
0192415X → ACNP
Volume
29
Issue
1
Year of publication
2001
Pages
111 - 118
Database
ISI
SICI code
0192-415X(2001)29:1<111:TIEOHM>2.0.ZU;2-4
Abstract
Dai-Kenchu-To (DKT) is a herbal medicine and is currently used as the treat ment of paralytic ileus in Japan. We investigated the mechanism of benefici al effects of DKT in vitro. DKT-extract powder (DKT-EP; 30-300 mug/ml) caus ed a significant inhibition on carbachol (CCH; 10(-6))-induced contraction in a concentration dependent manner of the rat distal colon. DKT-EP (100 mu g/ml) consists of 20 mug/ml of Zanthoxylum Fruit, 30 mug/ml of Ginseng Root and 50 mug/ml of Ginger Rhizome. Although each of them had no effect on CC H-induced muscle contraction, the combination of three ingredients caused a significant inhibition on CCH-induced contraction.