Effects of Orengedoku-to and Senkanmeimoku-to, traditional herbal medicines, on the experimental elevation of aqueons flare in pigmented rabbits

We investigated the effects of Orengedoku-to (Huanglian-Jie-Du-Tang in Chin ese) and Senkanmeimoku-to (Xygan-Ming-Mu-Tang in Chinese), traditional herb al medicines, on experimantal elevation of aqueous flare in pigmented rabbi ts. To produce the elevation of aqueous aqueous flare in rabbits, prostagla ndin E-2 (PGE(2)) was applied to the cornea with use of a glass cylinder, o r lipopolysaccharides (LPS) were injected into the ear vein. Animals were p retreated by the oral administration of 150 g/day of food containing 0.7%, 0.2% or 0.07% (w/w) Orengedoku-to, or 2%, 0.6% or 0.2% (w/w) Senkanmeimoku- to for 5 days. Aqueous flare was measured with a laser flare-cell meter. Pr etreatment with 0.7% or 0.2% Orengedoku-to and 2% Senkanmeimoku-to did supp ress significantly (P < 0.05) elevation of aqueous flare induced by PGE(2). Pretreatment with 0.7% or 0.2% Orengedoku-to and 2% or 0.6% Senkanmeimoku- to significantly suppressed (P < 0.001) elevation of aqueous flare induced by LPS. It is possible that Orengedoku-to and Senkanmeimoku-to may migrate some forms of uveitis.