G. Franzios et al., INSECTICIDAL AND GENOTOXIC ACTIVITIES OF MINT ESSENTIAL OILS, Journal of agricultural and food chemistry, 45(7), 1997, pp. 2690-2694
The essential oils (EOs) extracted from the mint species Mentha pulegi
um and Mentha spicata, together with their main constituents, pulegone
, menthone, and carvone, were tested for insecticidal and genotoxic ac
tivities on Drosophila melanogaster. The EOs of both aromatic plants s
howed strong insecticidal activity, while only the oil of M. spicata e
xhibited a mutagenic one. Among the constituents studied, the most eff
ective insecticide was found to be pulegone, while the most effective
for genotoxic activity was menthone. Data show that both toxic and gen
otoxic activities of the EOs of the two studied mint plants are not in
accordance with those of their main constituents, pulegone, menthone,
and carvone. Pulegone is significantly more effective (9 times) as an
insecticide, while menthone and carvone are less effective (6 and 2 t
imes, respectively) insecticides when used in their authentic: forms,
and a mixture of authentic pulegone and menthone, in levels resembling
their content in the oil of M. pulegium, showed that the strong toxic
ity of pulegone is suppressed in the presence of menthone. All the abo
ve suggest that synergistic/antagonistic phenomena may be involved tha
t alter the toxicity of the whole EO.