Intrasellar pituicytoma in a patient with other endocrine neoplasms

Considered a neoplasm of pituicytes, pituicytoma is a rare and distinct typ e of glioma that arises in the suprasellar space and within the sella turci ca. Only 12 previously reported cases of pituicytoma are documented in the literature. We report an intrasellar pituicytoma in a 66-year-old man prese nting with symptoms and radiologic appearance indistinguishable from a nonf unctional pituitary adenoma. The patient also had a medical history signifi cant for parathyroid adenomas and follicular carcinoma of the thyroid. The intrasellar tumor had morphologic features of a pituicytoma, with interlaci ng fascicles and a storiform pattern much like a benign fibrous histiocytom a. Immunoreactivity for S100 was strong, but the tumor lacked intercellular collagen type IV. The differential diagnosis of a low-grade spindle cell l esion of the sellar space is discussed, and the literature is reviewed. A s ummary of the clinical and pathologic features of this case, as well as the 12 previously reported cases, is presented.