Live donor adult liver transplantation using right lobe grafts - Donor evaluation and surgical outcome

Hypothesis: Live donor adult liver transplantation (LDALT) is a safe and ef ficacious treatment for patients with end-stage liver disease. Design: Case-control study. Setting: Hepatobiliary surgery and liver transplantation unit. Patients; From December 10, 1998, through April 10, 2000, a single team per formed 15 LDALT procedures with 2 simultaneous living do nor kidney transpl ants. During this period, 66 potential donors were screened and evaluated. Interventions: Potential donors were evaluated with 3-dimensional helical c omputed tomographic scan, including volume renderings for hepatic lobar vol ume, vascular anatomy, virtual resection planes, and morphologic features. Suitable donors undergo complete medical and psychiatric evaluation and pre operative arteriography. Main Outcome Measures: Donor demographics, evaluation data, operative data, hospital length of stay, and morbidity. Results: A total of 38 men (58%) and 28 women (42%) were evaluated with 15 donors participating in LDALT. Two additional donors provided kidney grafts for simultaneous transplantation at the time of LDALT. Thirty-two donors ( 48%) were rejected for either donor or recipient reasons, and 10 patients ( 15%) elected not to participate after initial screening. Three-dimensional volume renderings by helical computed tomographic scan predicted right lobe liver volume within 92% of actual graft volume. Donor morbidity, including all complications, was 67% with no mortality. Residual liver regenerated t o approximately 70% of initial volume within 1 week and 80% within 1 month after surgery. Conclusions: Donor evaluation is an important component of LDALT. Significa nt donor morbidity is encountered even with careful selection. To minimize donor morbidity, groups considering initiating living donor programs should have expertise in hepatic resection and vena cava preservation using the " piggyback" technique during liver transplantation.