The stability of metal-free very massive stars (Z = 0; M = 120-500 M-circle
dot) is analyzed and compared with metal-enriched stars. Such zero-metalli
city stars are unstable to nuclear-powered radial pulsations on the main se
quence, but the growth timescale for these instabilities is much longer tha
n for their metal-rich counterparts. Since they stabilize quickly after evo
lving off the zero-age main sequence (ZAMS), the pulsation may not have suf
ficient time to drive appreciable mass loss in Z = 0 stars. For reasonable
assumptions regarding the efficiency of converting pulsational energy into
mass loss, we find that, even for the larger masses considered, the star ma
y die without losing a large fraction of its mass. We find a transition bet
ween the epsilon- and kappa -mechanisms for pulsational instability at Z si
milar to 2 x 10(-4) to 2 x 10(-3). For the most metal-rich stars, the kappa
-mechanism yields much shorter e-folding times, indicating the presence of
a strong instability. We thus stress the fundamental difference of the sta
bility and late stages of evolution between very massive stars born in the
early universe and those that might be born today.