Iotroridoside-A, a novel cytotoxic glycosphingolipid from the marine sponge Iotrochota ridley

A new cytotoxic glycosphingolipid, Iotroridoside-A, was isolated from the m arine sponge lotrochota ridley collected from the South China Sea near Hain an Island, China. On the basis of chemical degradation method and IR, MS, H -1 NMR, C-13 NMR and 2D NMR spectrometry, its structure was assigned as 1-O -beta -D-glucopyranosyl-2-[(4' Z)-2'-hydroxytetracosene amido]-4-tetradecyl -1, 3, 4-butantriol. The new compound exhibits strong cytotoxicity against L1210 murine leukemia cells in vitro (ED50 = 0.08 mug/mL).