ICHTHYOSIFORM SARCOIDOSIS

A 24-year-old Japanese woman presented with a two-month history of an asymptomatic, dry and scaly condition on her lower legs. Six months ea rlier, she was diagnosed as suffering from sarcoidosis because of uvei tis, enlargement of bilateral hilar lymphadenopathy on chest X-ray and high levels of serum angiotensin-converting enzyme. The ichthyosiform lesion is a rare skin manifestation of sarcoidosis. Histological exam ination revealed non-caseating epithelioid cell granulomas from the up per dermis to subcutaneous fat tissue. We also observed granulomas aro und the eccrine sweat glands which might be responsible for the hypofu nction of the eccrine glands, perhaps leading to the ichthyosiform eru ption.