DEFINITION OF ENERGETICALLY SIGNIFICANT P ARTS OF GLOBULE AND HIERARCHY OF DOMAIN-STRUCTURE OF MACROMOLECULE OF PROTEIN

We have justified a Van der Waals approach for the problem of domains structure in globular proteins. A method for isolation of hierarchy of Van der Waals interactions in the space of protein globule has been f ound out. The definition of hierarchy's levels in the spatial structur e of macromolecules Is effected by the position of maxima in the distr ibution of potential energy of interactions. Multilevels system for do main structure organization of globular proteins and method for isolat ion of domains on different levels of energetical hierarchy has been e stablished. Using this method we have revealed regions of different st ability in 15 proteins globule.