INDUCTION AND SUPPRESSION OF RAT THYMOCYT E APOPTOSIS BY ULTRAVIOLET-IRRADIATION

Authors
LONSKAYA IA AFANASYEV VN PECHATNIKOV VA
Citation
Ia. Lonskaya et al., INDUCTION AND SUPPRESSION OF RAT THYMOCYT E APOPTOSIS BY ULTRAVIOLET-IRRADIATION, Biofizika, 42(3), 1997, pp. 680-686
Citations number
26
Categorie Soggetti
Biophysics
Journal title
Biofizika → ACNP
ISSN journal
00063029
Volume
42
Issue
3
Year of publication
1997
Pages
680 - 686
Database
ISI
SICI code
0006-3029(1997)42:3<680:IASORT>2.0.ZU;2-Q
Abstract
Flow cytometry was used to investigate the effect of 254 nm wavelength UV irradiation on single rat thymocytes suspension in vitro The Induc tion of apoptosis has been observed in dose range less 20 J/m(2). More high UV doses inhibited thymocyte apoptosis induced by dexamethasone, ionizing radiation and by UV Itself. The necessity of protein kinase C activation has been demonstrated for realization of such dual effect of UV (apoptosis Induction and supression).