Nucleophilic substitution reaction on the nitrogen of indole nucleus: Formation of 1-(indol-3-yl)indole upon reaction of 1-hydroxyindoles with indolein formic acid

Authors
Somei, M Yamada, F Hayashi, T Goto, A Saga, Y
Citation
M. Somei et al., Nucleophilic substitution reaction on the nitrogen of indole nucleus: Formation of 1-(indol-3-yl)indole upon reaction of 1-hydroxyindoles with indolein formic acid, HETEROCYCLE, 55(3), 2001, pp. 457-460
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
55
Issue
3
Year of publication
2001
Pages
457 - 460
Database
ISI
SICI code
0385-5414(20010301)55:3<457:NSROTN>2.0.ZU;2-7
Abstract
1-(Indol-3-yl)indoles are obtained in excellent to good yields by the react ion of 1-hydroxyindoles with indole in 85% formic acid. Their structures ar e determined by X-Ray crystallographic analysis and chemical correlations. The unprecidented SN2 mechanism on the indole nitrogen is proposed.