A radical synthetic approach to the new potentially bioactive pyrimidinones

Authors
Djekou, S Gellis, A Maldonado, J Crozet, MP Vanelle, P
Citation
S. Djekou et al., A radical synthetic approach to the new potentially bioactive pyrimidinones, HETEROCYCLE, 55(3), 2001, pp. 535-544
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
55
Issue
3
Year of publication
2001
Pages
535 - 544
Database
ISI
SICI code
0385-5414(20010301)55:3<535:ARSATT>2.0.ZU;2-G
Abstract
2-Chloromethyl-8-methyl-3-nitro-4H-pyrido[1,2-a]pyrimidin-4-one was shown t o react with various nitronate or malonate anions under mild conditions to give potentially bioactive nitro-4H-pyrido[1,2-a]pyrimidin-4-ones. Extensio n to other anions centred on S or O atom allows to generalize this syntheti c procedure.