Identification of four novel dinucleotide repeat polymorphisms in the IL-2and IL-2 beta receptor genes

Two polymorphic regions have been described within the IL-2 and IL-2 recept or P genes comprising 15 and 8 alleles, respectively. Whether these polymor phisms have biologic importance is unknown, although they have been variabl y identified in associated with certain chronic disease states. We report h ere the detection of four new alleles designated IL-2 A* (122 bp), IL-2R-2 (169 bp), IL-2R 0 (165 bp), and IL-2R 9 (147 bp) in patients with rheumatoi d arthritis and normal controls from the Pacific Northwest. The number of a lleles now recognized at these loci within the IL-2 and IL-2R beta genes in creases to 16 and 12, (C) American Society for Histocompatibility and Immun ogenetics, 2001. Published by Elsevier Science Inc.