SUCCESSIVE TRANSFORMATION OF CHRONIC MYELOMONOCYTIC LEUKEMIA INTO ACUTE MYELOBLASTIC THEN LYMPHOBLASTIC-LEUKEMIA, BOTH WITH MINOR-BCR REARRANGEMENT

Authors
DAUTEL MM FRANCOIS S BERTHEAS MF BARANGER L GARDAIS J BOASSON M IFRAH N BLANCHET O
Citation
Mm. Dautel et al., SUCCESSIVE TRANSFORMATION OF CHRONIC MYELOMONOCYTIC LEUKEMIA INTO ACUTE MYELOBLASTIC THEN LYMPHOBLASTIC-LEUKEMIA, BOTH WITH MINOR-BCR REARRANGEMENT, British Journal of Haematology, 98(1), 1997, pp. 210-212
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
98
Issue
1
Year of publication
1997
Pages
210 - 212
Database
ISI
SICI code
0007-1048(1997)98:1<210:STOCML>2.0.ZU;2-W
Abstract
We report a case of chronic myelomonocytic leukaemia (CMML), which tra nsformed first into acute myeloblastic leukaemia (AML) and then into a cute lymphoblastic leukaemia (ALL). In the AML and ALL phases, chromos ome analysis showed a classic Philadelphia chromosome (Ph) t(9;22)(q34 ;q11). Molecular studies showed breakpoint cluster region rearrangemen t between exons e1 and a2 compatible with a p190(bcr/abl) breakpoint a s observed in Ph-positive lymphoblastic acute leukaemia. The minor (m- bcr) rearrangement was also detected during complete remission. This o bservation supports a multistep pathogenesis of leukaemias, and that t he p190(bcr/abl) breakpoint may influence the course of the disease.