A new method for pulse oximetry is presented that possesses an inherent ins
ensitivity to corruption by motion artifact, a primary limitation in the pr
actical accuracy and clinical applicability of current technology, Artifact
corruption of the underlying photoplethysmographic signals is reduced in r
eal time, using an electronic processing methodology that is based upon inv
ersion of a physical artifact model. This fundamental approach has the pote
ntial to provide uninterrupted output and superior accuracy under condition
s of sustained subject motion, therefore, widening the clinical scope of th
is useful measurement. A new calibration technique for oxygen saturation is
developed for use with these processed signals, which is shown to be a gen
eralization of the classical interpretation. The. detailed theoretical and
practical issues of implementation are then explored, highlighting importan
t engineering simplifications implicit in this new approach. A quantitative
investigation of the degree of insensitivity to artifact is also undertake
n, with the aid of a custom electronic system and commercial pulse oximeter
probes, which is compared and contrasted with the performance of a convent
ional implementation, It is demonstrated that this new methodology results
in a reduced sensitivity to common classes of motion artifact, while retain
ing the generality to be combined with conventional signal processing techn
iques.