Synthesis of some 4-(arylmethylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones

Authors
Kahveci, B Serdar, M Ikizler, AA
Citation
B. Kahveci et al., Synthesis of some 4-(arylmethylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones, I J HET CHE, 10(3), 2001, pp. 201-204
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
09711627 → ACNP
Volume
10
Issue
3
Year of publication
2001
Pages
201 - 204
Database
ISI
SICI code
0971-1627(200101/03)10:3<201:SOS4>2.0.ZU;2-E
Abstract
A series of 3-alkyl-4-(arylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-o nes 2 were obtained and reduced with NaBH4 as a selective reducing agent to afford 3-alkyl-4-(arylmethylamino)-4,5-dihydro-1 H-1,2,4-triazol-5-ones 3. So 15 new compounds were synthesized and characterized by elemental analys es, H-1 NMR, IR and UV spectra. Three of these compounds were-screened for their antitumor activities.