Synthesis and biological evaluation of some pyrimidinethiones and related heterocycles

Anilide derivatives (1a) and (1b) have been prepared and cyclized with vari ous aromatic aldehydes and thiourea to yield the corresponding 4-aryl-5-ary lcarbamoyl-3,4-dihydro-6-methyl-2 (1H) pyrimidinethiones (2a-j), compounds (2a-j) were treated with Mel to yield respective 4-aryl-5-N-arylcarbamoyl-6 -methyl-2-methylthio-3,4-dihydropyrimidines (3a-j). The structure of the co mpounds (2a-j) and (3a-j) have been elucidated by elemental analysis and sp ectral data. All the products have been screened for their in vitro growth inhibitory activity against several microbes like B. megaterium, B. subtili s, E. coli Ps. fluorescens and A. awamori.